Research position available

One temporary short-term position is now available! The project aims to develop and employ (i) an innovative in vivo system allowing the differentiation, monitoring, retrieval, characterization and modulation of MODY-iPSC-derived β-cells; (ii) methods for characterizing the cellular processes and molecular…

Invited Speaker: NATALIA SOSHNIKOVA

We have the pleasure of hosting Dr. Natalia Soshnikova from the Institute of Molecular Biology (IMB), Mainz, Germany. She will talk about the molecular mechanisms of intestinal stem cell specification during development on 18th of January 2018 at BUS1 Pankreas…

Collaboration Paper: Converting Adult Pancreatic Islet α Cells into β Cells by Dnmt1-Arx

Chakravarthy et al. dissect the mechanisms maintaining α cell identity and reveal that simultaneous inactivation of the DNA methyltransferase Dnmt1 and the transcription factor Arx in adult mice drives the conversion of α- to β-like cells. In human T1D islets, glucagon+ cells lose DNMT1 and ARX expression and express β cell markers.