Simona and Luiza will present some work progress on different projects running in the lab at the Bergen Stem Cell Consortium Research Seminar on Friday, 12th of April 2019 at Glasblokkene
Bergen Stem Cell Consortium Research Seminar
3rd Joint EASD Islet and Beta-Cell Workshop
Here, Thomas was enjoying good company in Oxford at the 3rd Joint EASD Islet and Beta-Cell Workshop. He also did a good job presenting a poster on our work on alginate encapsulation. Lise Bjørkhaug Gundersen, Thomas Aga Legøy, Marie Holm…
Travel Grants from Nordic Developmental Biology Organisations
The Nordic Developmental Biology organisations are announcing travel grants of 6000 SEK each, to help its members at the postdoctoral and graduate student level to attend courses, meetings or workshops during the year 2019 that promote their research and education…
Meeting report LUDC, Bergen, FIMM meeting in Malmö (20-21 March)
Two weeks ago, researchers from three institutions: Lund University Diabetes Centre (LUDC), Bergen Diabetes Groups and FIMM met in the spacious Agardh lecture hall of CRC, in Malmö, to attend a workshop titled “Extremism can be useful”. The workshop was…
Collaboration Paper: glucose-sensing insulin-secreting human α-cells
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing…
Invited Speaker: BRIGITTE GALLIOT
We have the pleasure of hosting Prof. Brigitte Galliot from the Faculty of Sciences, University of Geneva, Switzerland. The seminar is organized in collaboration with SARS and will take place at HiB, Bioblokken 5th floor, Room 520B (Thormøhlensgt. 55, 5006…
Research position available
One temporary short-term position is now available! The project aims to develop and employ (i) an innovative in vivo system allowing the differentiation, monitoring, retrieval, characterization and modulation of MODY-iPSC-derived β-cells; (ii) methods for characterizing the cellular processes and molecular…
Research Paper: Specific protein signatures related to progression to muscular invasiveness in bladder cancer
Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent…
Collaboration Paper: Signals modulating identity changes of pancreatic α-cells
The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1-2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plasticity.…
Invited Speaker: NATALIA SOSHNIKOVA
We have the pleasure of hosting Dr. Natalia Soshnikova from the Institute of Molecular Biology (IMB), Mainz, Germany. She will talk about the molecular mechanisms of intestinal stem cell specification during development on 18th of January 2018 at BUS1 Pankreas…
Research Paper: β-cell proteomic landscape in differentiating MODY1 patient iPSC-derived cells
Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of…
Collaboration Paper: Converting Adult Pancreatic Islet α Cells into β Cells by Dnmt1-Arx
Chakravarthy et al. dissect the mechanisms maintaining α cell identity and reveal that simultaneous inactivation of the DNA methyltransferase Dnmt1 and the transcription factor Arx in adult mice drives the conversion of α- to β-like cells. In human T1D islets, glucagon+ cells lose DNMT1 and ARX expression and express β cell markers.