Here, Andreas built and analysed several timelines along the first year of life of different mouse models to understand how pancreatic endocrine islets are maturing and then age. By combining transgenic systems, global transcriptomics, pathway analysis, cell biology and physiology,…
Rethinking the Overshadowed by Shayla Sharmine Glucose homeostasis in the human body is maintained through a delicate balance between glucose production, uptake, and storage, primarily regulated by endocrine hormones secreted from the pancreas. While insulin from β cells and glucagon…
Congratulations to Kayko who received funding from the L. Meltzers Universitetsstiftelse for the proposal titled ”Deciphering the role of WNT4 in bladder cancer using patient-derived organoids”! Bladder cancer (BC) is the most common cancer of the urinary tract and currently…
by Thomas Aga Legøy Bisphenol S (BPS) is extensively utilized in various commercial and manufacturing products, including cleaning detergents, plating solvents, phenolic resins, and thermal paper. Previous studies have demonstrated that BPS is closely associated with acute cytotoxicity, neurotoxicity, immunotoxicity,…
Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…
The Scandinavian Physiological Society’s 100th anniversary will be celebrated on the 11th of September – during the IUPS/Europhysiology 2025 meeting in Frankfurt/Main. This memorable evening will include a trip down memory lane guided by the original foundation records for SPS…
by Kaykobad Hossain Bladder cancer, like most cancers, is a heterogenous disease and the variability of the disease can be captured using molecular subtyping, which may result in more effective treatment options. Even though bladder cancer has been classified to…
by Ulrik Larsen Glucagon is traditionally seen as a pancreas-specific hormone, but evidence suggests an extra-pancreatic source that responds abnormally to oral glucose in diabetic patients. This study investigates whether the intestine could be responsible for this unexpected glucagon secretion. …
by Lucas Unger The differentiation of human pluripotent stem cells into insulin-producing beta cells holds great potential for both transplantation-based treatment of insulin-dependent diabetes and diabetes research. In this study, a comprehensive analysis of publicly available single-cell RNA sequencing data…
A Short visit to the research: by Shayla Sharmine Intermittent fasting (IF) is a widely studied dietary intervention known for its metabolic benefits, including improved glucose homeostasis and insulin sensitivity. While IF has shown positive effects in adult and aging…
by Fatemeh Rahmatabadi Acute myeloid leukemia (AML) is the most common myeloid cancer in adults, arising from hematopoietic stem cells and marked by a rapid proliferation of immature myeloblasts. Its genetic and clinical diversity complicates treatment. Key mutated genes include…
by Thomas Aga Legøy The gut microbiota has garnered significant attention in recent years due to its critical role in maintaining physiological health. A balanced gut microbiota is associated with overall well-being, whereas dysbiosis is linked to the development and…
