Rethinking the Overshadowed by Shayla Sharmine Glucose homeostasis in the human body is maintained through a delicate balance between glucose production, uptake, and storage, primarily regulated by endocrine hormones secreted from the pancreas. While insulin from β cells and glucagon…
Congratulations to Kayko who received funding from the L. Meltzers Universitetsstiftelse for the proposal titled ”Deciphering the role of WNT4 in bladder cancer using patient-derived organoids”! Bladder cancer (BC) is the most common cancer of the urinary tract and currently…
by Thomas Aga Legøy Bisphenol S (BPS) is extensively utilized in various commercial and manufacturing products, including cleaning detergents, plating solvents, phenolic resins, and thermal paper. Previous studies have demonstrated that BPS is closely associated with acute cytotoxicity, neurotoxicity, immunotoxicity,…
Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…
by Kaykobad Hossain Bladder cancer, like most cancers, is a heterogenous disease and the variability of the disease can be captured using molecular subtyping, which may result in more effective treatment options. Even though bladder cancer has been classified to…
by Ulrik Larsen Glucagon is traditionally seen as a pancreas-specific hormone, but evidence suggests an extra-pancreatic source that responds abnormally to oral glucose in diabetic patients. This study investigates whether the intestine could be responsible for this unexpected glucagon secretion. …
by Lucas Unger The differentiation of human pluripotent stem cells into insulin-producing beta cells holds great potential for both transplantation-based treatment of insulin-dependent diabetes and diabetes research. In this study, a comprehensive analysis of publicly available single-cell RNA sequencing data…