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Category: Publications
Research Paper: Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo
We are very happy to share our latest work on how HNF1A’s involvement in GLI3 processing affects pancreatic and intestinal development, using a combination of in vivo work (multiple conditional mouse models) and human iPSC models is now ONLINE ahead of print in Genes and Development
Research Paper: Endocrine Disrupting Chemical Exposure During Differentiation Alters the Proliferation-Maturation Balance in Stem-Cell islets
This study proposes hiPSCs derived SC-islet differentiation as model to study development impact of EDCs on human pancreatic endocrine cell development and maturation. Using a cocktail of BPA, BPS and trans-nonachlor provided comparable results with in vivo studies of fetus exposure to BPA. Congratulations June, Thomas and Lucas!
Research Paper: Caloric Restriction Substantially Improves Glucose Regulation in Mice With Hnf1a‐Deficient Beta‐Cells
Our work on the impact of diet challenges on Hnf1a-deficient beta-cells is now published in Acta Physiologica! Congratulations Shayla, Thomas and Lucas!
Research Paper: Efficient cytoplasmic cell quantification using a semi-automated FIJI-based tool
A tour-de-force demonstrating the abilities of Lucas‘s quantitation tool (previously available as a preprint) on pancreatic islet cell quantitation is now published in Scientific Reports! The source code of SAM (semi-automated measurement tool) along with all documentation has been deposited…
Editorial: Targeting Inflammation in Type 2 Diabetes: The Emerging Role of Decorin
Shayla Sharmine and I had the opportunity to write an editorial about recent work published in Acta Physiologica on the role of Decorin on pancreatic islets. Shayla did a really great job on generating a nice figure summarising the published…
Research Paper: Mapping the initial effects of carcinogen-induced oncogenic transformation in the mouse bladder
Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…