Category: Journal Club

8/12/2025 Kayko
8/19/2025 Fatemeh
8/26/2025 Camille
9/2/2025 Shayla
9/9/2025 Lucas
9/16/2025 Ulrik
9/23/2025 Georg
9/30/2025 Thomas

Journal Club: CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

by Lucas Unger Yang et al. demonstrate that HHEX is a lineage-restricting transcription factor essential for pancreas specification from foregut progenitors. Through CRISPR-Cas9 loss-of-function screening combined with hiPSC differentiation and single-cell multiomics, the study reveals that deletion of HHEX diverts…