Interview on UiB website

If you want to read about our research featured in an article published on the News of University of Bergen, please click on the following link: Studying single-gene disorders to cure diabetes    

FRIPRO Young Talent Research Project

The Norwegian Research Council announced on 7th of December the new list of awardees. We got new funding from FRIPRO for another independent Young Research Talent project: “Characterizing and modulating the insulin-producing beta-cell fate in monogenic diabetes by using novel…

The Novo Nordisk Foundation Excellence Project grant

Diabetes mellitus is a group of metabolic diseases defined by high blood sugar values caused by the inability of the body to produce and/or use insulin. All forms of diabetes are ultimately characterized by a decrease in the number of functional insulin-producing cells (β-cells), hence a cure for insulin-dependent diabetes types will require their regeneration or replacement. Generally, the most efficient regenerative strategies are the ones involving cell self-renewal capacity. Nevertheless, in mammals, the β-cell proliferative capacity is very low after birth and decreases even further with age. The overall aim of this proposal is to elucidate and reverse the molecular age-switch controlling the gradual impairment of β-cell self-renewal potential by using two murine models of monogenic diabetes.

MODY – our research model

MODY (maturity-onset diabetes of the young) is caused by pancreatic beta cell dysfunction due to a single gene mutation affecting both the prenatal and postnatal pancreas development. Importantly, more than 90 % of MODY mutation carriers will develop diabetes during…