Research Paper: hyperglycemia effects on human pancreatic progenitor differentiation, conveyed by oxidative stress

Our latest work on iPSC-derived human pancreatic progenitors differentiation is now out for Early View:

• The main goal of this study was to characterize global effect of brief and prolonged in vivo hyperglycaemia exposure on the cell fate acquisition and maintenance of transplanted human pancreatic progenitors.
• The cell fate and proteome landscape response to hyperglycaemia was different, involving largely distinct mechanisms, according to the period spent in the hyperglycaemic environment.
• Brief hyperglycaemia exposure increased the bihormonal cell number by impeding the activity of specific islet lineage determinants. Moreover, it activated antioxidant and inflammation protection mechanisms signatures in the transplanted cells.
• The prolonged exposure was characterized by decreased numbers of hormone + cells, low/absent detoxification signature, augmented production of oxygen reactive species and increased apoptosis.

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In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress

Authors: Legøy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S. Acta Physiol (Oxf) 2019 Dec 23:e13433. PMID:31872528

DOI information: 10.1111/apha.13433