Please help us disseminate our research by watching, like and share a movie made by Lucas on his latest publication!
Watch Lucas’ Movie explaining our latest published article
Tag: cell fate
Research Paper: Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo
We are very happy to share our latest work on how HNF1A’s involvement in GLI3 processing affects pancreatic and intestinal development, using a combination of in vivo work (multiple conditional mouse models) and human iPSC models is now ONLINE ahead of print in Genes and Development
Research Paper: Mapping the initial effects of carcinogen-induced oncogenic transformation in the mouse bladder
Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…
Research Paper: Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption
Here, we investigated the regenerative response of pancreatic islets following moderate beta-cell loss in mice using two diffenet models: one rapid beta-cell targeted synchronous cell death by using the RIPDTR model, and one slow heterogeneous cell death by using streptozotocin…
Research Paper: Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset
Together with our collaborators from the BETAUPREG Group (financed by NO Grants 2014– 2021, under Project contract no. 21/2020 (RO-NO-2019-0544), Andreas and Andrei mapped the molecular fingerprint of early insulitis in a cohort of NOD mice ranging from 4 to…
Research Paper: The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop
Here, Andreas built and analysed several timelines along the first year of life of different mouse models to understand how pancreatic endocrine islets are maturing and then age. By combining transgenic systems, global transcriptomics, pathway analysis, cell biology and physiology,…
Research Paper: The GLI code controls HNF1A levels during foregut differentiation
During pancreas development the HH-signaling modulations plays an essential role, its inactivation being absolutely required for pancreas organogenesis, even slight ectopic activation compromising this process. Moreover, the pathway also plays a role in adult pancreas regeneration, its inactivation promoting regenerative…