Collaboration Paper: Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss

A detailed study into alpha-cells transcriptional changes upon massive ablation of beta-cells carried out in collaboration with Dr. Santiago Rodríguez-Seguí  and Prof. Pedro Herrera groups was published today, and we show that: α-cells undergo stage-specific transcriptional changes 5- and 15-days…

Book Chapter: A Method for Encapsulation and Transplantation into Diabetic Mice of hiPSC-Derived Pancreatic Progenitors

Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.…

Collaboration Paper: The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas

I had recently the great pleasure to contribute to a collaboration study led by Dr. Charna Dibner (from the Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva) deciphering the…