by Ulrik Larsen Glucagon is traditionally seen as a pancreas-specific hormone, but evidence suggests an extra-pancreatic source that responds abnormally to oral glucose in diabetic patients. This study investigates whether the intestine could be responsible for this unexpected glucagon secretion. …
by Lucas Unger The differentiation of human pluripotent stem cells into insulin-producing beta cells holds great potential for both transplantation-based treatment of insulin-dependent diabetes and diabetes research. In this study, a comprehensive analysis of publicly available single-cell RNA sequencing data…
A Short visit to the research: by Shayla Sharmine Intermittent fasting (IF) is a widely studied dietary intervention known for its metabolic benefits, including improved glucose homeostasis and insulin sensitivity. While IF has shown positive effects in adult and aging…
by Fatemeh Rahmatabadi Acute myeloid leukemia (AML) is the most common myeloid cancer in adults, arising from hematopoietic stem cells and marked by a rapid proliferation of immature myeloblasts. Its genetic and clinical diversity complicates treatment. Key mutated genes include…
by Thomas Aga Legøy The gut microbiota has garnered significant attention in recent years due to its critical role in maintaining physiological health. A balanced gut microbiota is associated with overall well-being, whereas dysbiosis is linked to the development and…
Many congratulations to Jakub and Marc on developing a new Python-based tool called ProHap that constructs protein sequence databases from phased genotypes of reference panels, and comes with pregenerated databases from field-reference haplotype panels. Thus ProHap empowers researchers to account…
Four Master students at Master in Biomedical Sciences begun a 7-weeks internship in our lab from October 2024. Dominika Aleksandra Hawryluk and Georg Cato Seeberg will work with Ulrik, while Agnes Hager and Ingrid Sofie Oveland Apelseth will work with…
World Diabetes Day is organized also this year by the Mohn Center for Diabetes Precision Medicine (PRECISE-DIA) at the University of Bergen on 14 November 2024. What’s happening: Family-friendly open laboratories with presentations and tours of laboratories. Free food and…
Another collaborative study carried over during Simona’s sabbatical stay in Prof Charna Dibner research group at University of Geneva aiming at profiling the long-term modifications of lipid metabolism associated with massive weight loss following the Roux-en-Y gastric bypass surgery. Here, we…
Simona recently was invited by the organizers to share her expertise on human induced pluripotent stem cells (hiPSCs) at the next “How To” Seminar (20th of August 2024) hosted by the Mohn Research Centre for Regenerative Medicine (MRCRM). For more…
Congratulations to Kayko, who has received a most-wanted PhD fellowship from the Faculty of Medicine, UiB. #PhDlife Kayko will start his project next month working on the molecular mechanisms driving regeneration and tumorigenesis in the urotheium aiming at identifying a…
Here, we investigated the regenerative response of pancreatic islets following moderate beta-cell loss in mice using two diffenet models: one rapid beta-cell targeted synchronous cell death by using the RIPDTR model, and one slow heterogeneous cell death by using streptozotocin…