It’s hard to believe that Thomas is leaving us! While we will miss your presence here, we know you will achieve great things in your new adventure.
Farewell to: Thomas Aga Legøy
Journal Club: Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived ϐ-cells
by Agnes Sandvik: This week’s journal club focuses on a study from BMC Genomics (2024) using single-cell sequencing datasets to characterize the transcriptional identity of islets from in vitro differentiation, fetal islets, and adult islets
10th Meeting of the Study Group on Genetics of Diabetes, May 6 – 8, 2026
Our institute is organising the 10th Meeting of the Study Group on Genetics of Diabetes (SGGD) which will take place in Solstrand, near Bergen between 6th – 8th of May, 2026. Abstract submissions Abstract submission are opened until 2nd of…
Grant award: The Norwegian Cancer Society
Absolutely thrilled to announce that we have been awarded funding from @Kreftforeningen to continue our work on bladder tumor biology! Many plans and experiments are now possible and we are delighted to continue our work on the research project Mapping the…
Speaking at CCBIO Seminar: Luiza Ghila
Luiza will give a talk about new developments in the lab and work on bladders at the next CCBIO Seminar (11th of December 2025, 14:30).
Journal Club: Pharmacology and toxicology of the novel investigational agent Cantrixil
by Fatemeh Rahmatabadi: This week’s journal club focuses on a study from Cancer Chemother. Pharmacol. (2017) promoting Cantrixil as a promising anti-cancer agent targeting resilient cancer-stem–cell populations.
Research Paper: Endocrine Disrupting Chemical Exposure During Differentiation Alters the Proliferation-Maturation Balance in Stem-Cell islets
This study proposes hiPSCs derived SC-islet differentiation as model to study development impact of EDCs on human pancreatic endocrine cell development and maturation. Using a cocktail of BPA, BPS and trans-nonachlor provided comparable results with in vivo studies of fetus exposure to BPA. Congratulations June, Thomas and Lucas!
Collaboration PrePrint: MODY mutations in transcription factors HNF1A and HNF1B affect the production of interferon signaling proteins: evidence at the proteome level
Our collaboration with our neighbouring lab continues with Ksenia performing quantitative label-free mass spectrometry, by employing both data-dependent and data-independent acquisition methods, on our cell line model for HNF1A “hot-spot” mutation. Lucas performed in vitro differentiation until pancreatic progenitor stage…
World Diabetes Day at Glasblokkene
On the occasion of World Diabetes Day, we invite you to a lunch seminar. The seminar starts with lunch at 11:00 in the auditorium in Glasblokkene, Block 8, and will offer two exciting lectures from Simon Dankel and Thomas Aga Legøy that will shed light on current topics within diabetes research.
Journal Club: Repeated head trauma causes neuron loss and inflammation in young athletes
by Ulrik: This week’s journal club focuses on a study from Nature (2025) characterizing the early cellular changes that might lead to chronic traumatic encephalopathy in young athletes exposed to repetitive head impacts.
Research Paper: Caloric Restriction Substantially Improves Glucose Regulation in Mice With Hnf1a‐Deficient Beta‐Cells
Our work on the impact of diet challenges on Hnf1a-deficient beta-cells is now published in Acta Physiologica! Congratulations Shayla, Thomas and Lucas!
Journal Club: Trametinib Sensitivity is Defined by a Myeloid Differentiation Profile in Acute Myeloid Leukemia
by Fatemeh Rahmatabadi: This week’s journal club focuses on a study from Drugs in R&D (2024) aiming to assess the activity of trametinib against a panel of tumor cells from patients with AML