We are very happy to annouce the publication of a study led by Dr. Ana Vacaru (Group Leader of the BetaUpreg Research Group, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania) investigating the link between bisphenol A (BPA) and endoplasmic reticulum (ER) stress, which upon induction activates the unfolded protein response (UPR), leading to impaired function of the β-cells.
This study focused on the impact of BPA on β-cell viability, the architecture of the early secretory pathway, the synthesis and processing of insulin and the activation of UPR sensors and effectors in MIN6 cells (mouse insulinoma cell line) and isolated pancreatic islets from NOR (non-obese diabetes resistant) mice. The addition of the chemical chaperone TUDCA rescues the deleterious effects of BPA, resulting in improved viability, morphology and function of the β-cells. In conclusion, this work indicates that modulators of UPR can be used as therapeutic interventions targeted towards regaining β-cells homeostasis.
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Authors: Laura Maria Daian, Gabriela Tanko, Andrei Mircea Vacaru, Luiza Ghila, Simona Chera and Ana-Maria Vacaru
Int. J. Mol. Sci. 2023, 24(3), 2023
DOI information: 10.3390/ijms24032023