by Shayla Sharmine This week’s journal club focuses on a study from Frontiers in Immunology (2025) aiming to assess the role of autophagy in b-cell health and survival, and whether defects in autophagy render islets more immunogenic.
by Camille Belliard: This week’s journal club discusses a landmark first-in-human study published in Cell (2024) investigating autologous transplantation of chemically induced pluripotent stem cell-derived islets (CiPSC-islets) for type 1 diabetes (T1D).
by Fatemeh Rahmatabadi Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation. Enzenmüller et al. explore why B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells sometimes resist the BCL-2 inhibitor…
by Kaykobad Hossain: in this article, researchers applied adhesion measurements of cancer cells to predict metastatic ability in a mouse model.
A tour-de-force demonstrating the abilities of Lucas‘s quantitation tool (previously available as a preprint) on pancreatic islet cell quantitation is now published in Scientific Reports! The source code of SAM (semi-automated measurement tool) along with all documentation has been deposited…
Can Sex Difference shape glucose regulation? by Shayla Sharmine This week’s journal club focuses on a study from Biochemical and Biophysical Research Communications (2025) exploring the protective role of estrogen in glucose regulation. To explore the impact of sex difference,…
High fructose diet in early life is bad by Ulrik Larsen Inspired by a lab member constantly theorizing about HNF1A and the brain, I came across a study on how early-life high fructose exposure affects brain development, focusing on microglia…
by Lucas Unger Yang et al. demonstrate that HHEX is a lineage-restricting transcription factor essential for pancreas specification from foregut progenitors. Through CRISPR-Cas9 loss-of-function screening combined with hiPSC differentiation and single-cell multiomics, the study reveals that deletion of HHEX diverts…
Wishing good luck to Ulrik having his midway evaluation today! Thesis Title: “Mouse-ing around with islet cells: unveiling the tissue repair puzzle” Examining committee Internal examiner 1: Prof. Bjørn Tore Gjertsen Internal examiner 2: Dr. Heidrun Vethe Supervisors Simona Chera,…
by Fatemeh Rahmatabadi This study by Hirosawa et al. investigates the effect of the p38 MAPK inhibitor SB202190 on acute myeloid leukemia (AML) cells. While p38 signaling is typically associated with stress responses and growth inhibition, treatment of AML cell…
Camille Belliard, currently pursuing an engineering degree in biotechnology at ENSTBB (Bordeaux INP), started a 4-months summer internship in our lab (June-September 2025). Welcome! Camille will work with Lucas and Agnes on reprogramming T1D patient fibroblasts into iPSC and their…
Georg Cato Seeberg will start working on his Master Thesis for one year in our lab (2024-2025) as part of Master in Biomedical Sciences organised by the Department of Biomedicine. Georg will work with Lucas under the supervision of Simona on the…