Journal Club: Bisphenol S exposure promotes stemness of triple-negative breast cancer cells via regulating Gli1-mediated Sonic hedgehog pathway

by Thomas Aga Legøy Bisphenol S (BPS) is extensively utilized in various commercial and manufacturing products, including cleaning detergents, plating solvents, phenolic resins, and thermal paper. Previous studies have demonstrated that BPS is closely associated with acute cytotoxicity, neurotoxicity, immunotoxicity,…

Research Paper: Mapping the initial effects of carcinogen-induced oncogenic transformation in the mouse bladder

Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…

Journal Club: Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells

by Lucas Unger The differentiation of human pluripotent stem cells into insulin-producing beta cells holds great potential for both transplantation-based treatment of insulin-dependent diabetes and diabetes research. In this study, a comprehensive analysis of publicly available single-cell RNA sequencing data…

Collaboration Article: ProHap enables human proteomic database generation accounting for population diversity

Many congratulations to Jakub and Marc on developing a new Python-based tool called ProHap that constructs protein sequence databases from phased genotypes of reference panels, and comes with pregenerated databases from field-reference haplotype panels. Thus ProHap empowers researchers to account…