Journal Club: Bisphenol S exposure promotes stemness of triple-negative breast cancer cells via regulating Gli1-mediated Sonic hedgehog pathway

by Thomas Aga Legøy Bisphenol S (BPS) is extensively utilized in various commercial and manufacturing products, including cleaning detergents, plating solvents, phenolic resins, and thermal paper. Previous studies have demonstrated that BPS is closely associated with acute cytotoxicity, neurotoxicity, immunotoxicity,…

Research Paper: Mapping the initial effects of carcinogen-induced oncogenic transformation in the mouse bladder

Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…