Journal Club: CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

by Lucas Unger Yang et al. demonstrate that HHEX is a lineage-restricting transcription factor essential for pancreas specification from foregut progenitors. Through CRISPR-Cas9 loss-of-function screening combined with hiPSC differentiation and single-cell multiomics, the study reveals that deletion of HHEX diverts…

Midway Evaluation: Ulrik

Wishing good luck to Ulrik having his midway evaluation today! Thesis Title: “Mouse-ing around with islet cells: unveiling the tissue repair puzzle” Examining committee Internal examiner 1: Prof. Bjørn Tore Gjertsen Internal examiner 2: Dr. Heidrun Vethe Supervisors Simona Chera,…

Welcome Camille!

camille

Camille Belliard, currently pursuing an engineering degree in biotechnology at ENSTBB (Bordeaux INP) started a 4-months summer internship in our lab (June-September 2025). She will work with Lucas and Agnes on reprogramming T1D patient fibroblasts into iPSC and their differentiation…

Journal Club: Real time somatostatin detection assay reveals somatostatin hypersecretion in T2D patient derived single islets

by Shayla Sharmine The endocrine pancreas produces hormones that regulate glucose homeostasis in the body. Among three major regulatory hormone-producing cell types, delta cell is known to regulate the secretion of somatostatin that counter-regulates insulin and glucagon production through intra-islet…