For the past five years, our collaborator Helge Ræder and us showed that human induced pluripotent stem cells (hiPSC) provide an excellent tool for disease modelling. However, in vitro differentiation is highly sensitive to culture conditions. By re-creating a spatial…
I am very happy to announce that we got the cover of the December Issue: Thank you Miri for the immunofluorescence picture, yes – it looks like a mouse, doesn’t it!? Also, many thanks to Charna and Vlad for this…
I had recently the great pleasure to contribute to a collaboration study led by Dr. Charna Dibner (from the Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva) deciphering the…
What is NCMM? Centre for Molecular Medicine Norway (NCMM) is an international biomedical research centre, with the overall objective of translating basic medical research into clinical practice. NCMM is a part of UiO’s interdiciplinary focus on life sciences. In the…
Congratulation to Yngvild for her published article, in which our collaborators show that: some reprogrammed cell lines present an unstable state leading to spontaneously differentiate and change their cellular phenotype and colony morphology; by comparing the proteome landscapes of 20…
Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of…
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing…