Induced pluripotent stem cells as a source for generating pancreatic islet endocrine cells represent a great research tool for deciphering the molecular mechanisms of lineage commitment, a layered multi-step process. Additionally, targeted gene silencing by using GapmeRs, short antisense oligonucleotides,…
We had the pleasure to co-edit a Research Topic at Frontiers in Genetics and Frontiers in Endocrinology, aiming to provide a sample of current work focused on molecular pathways and cellular processes involved in the development, function, and dysfunction of…
For the past five years, our collaborator Helge Ræder and us showed that human induced pluripotent stem cells (hiPSC) provide an excellent tool for disease modelling. However, in vitro differentiation is highly sensitive to culture conditions. By re-creating a spatial…
Our latest work on iPSC-derived human pancreatic progenitors differentiation is now out for Early View: The main goal of this study was to assess the effects of elevated glucose concentrations exposure during the last stages of guided in vitro differentiation…
Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.…
I am very happy to announce that we got the cover of the December Issue: Thank you Miri for the immunofluorescence picture, yes – it looks like a mouse, doesn’t it!? Also, many thanks to Charna and Vlad for this…
I had recently the great pleasure to contribute to a collaboration study led by Dr. Charna Dibner (from the Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva) deciphering the…