Many congratulations to Jakub and Marc on developing a new Python-based tool called ProHap that constructs protein sequence databases from phased genotypes of reference panels, and comes with pregenerated databases from field-reference haplotype panels. Thus ProHap empowers researchers to account…
Another collaborative study carried over during Simona’s sabbatical stay in Prof Charna Dibner research group at University of Geneva aiming at profiling the long-term modifications of lipid metabolism associated with massive weight loss following the Roux-en-Y gastric bypass surgery. Here, we…
Here, we investigated the regenerative response of pancreatic islets following moderate beta-cell loss in mice using two diffenet models: one rapid beta-cell targeted synchronous cell death by using the RIPDTR model, and one slow heterogeneous cell death by using streptozotocin…
Together with our collaborators from the BETAUPREG Group (financed by NO Grants 2014– 2021, under Project contract no. 21/2020 (RO-NO-2019-0544), Andreas and Andrei mapped the molecular fingerprint of early insulitis in a cohort of NOD mice ranging from 4 to…
We are very happy to annouce the publication of a study led by Dr. Hanne Scholz focusing on cell identity dynamics and insights into insulin secretagogues when employing stem cell-derived islets for disease modeling. Here, Chencheng focused on understanding the…
Here, Andreas built and analysed several timelines along the first year of life of different mouse models to understand how pancreatic endocrine islets are maturing and then age. By combining transgenic systems, global transcriptomics, pathway analysis, cell biology and physiology,…
During pancreas development the HH-signaling modulations plays an essential role, its inactivation being absolutely required for pancreas organogenesis, even slight ectopic activation compromising this process. Moreover, the pathway also plays a role in adult pancreas regeneration, its inactivation promoting regenerative…