This study proposes hiPSCs derived SC-islet differentiation as model to study development impact of EDCs on human pancreatic endocrine cell development and maturation. Using a cocktail of BPA, BPS and trans-nonachlor provided comparable results with in vivo studies of fetus exposure to BPA. Congratulations June, Thomas and Lucas!
Our work on the impact of diet challenges on Hnf1a-deficient beta-cells is now published in Acta Physiologica! Congratulations Shayla, Thomas and Lucas!
A tour-de-force demonstrating the abilities of Lucas‘s quantitation tool (previously available as a preprint) on pancreatic islet cell quantitation is now published in Scientific Reports! The source code of SAM (semi-automated measurement tool) along with all documentation has been deposited…
Shayla Sharmine and I had the opportunity to write an editorial about recent work published in Acta Physiologica on the role of Decorin on pancreatic islets. Shayla did a really great job on generating a nice figure summarising the published…
Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…
Here, we investigated the regenerative response of pancreatic islets following moderate beta-cell loss in mice using two diffenet models: one rapid beta-cell targeted synchronous cell death by using the RIPDTR model, and one slow heterogeneous cell death by using streptozotocin…
Together with our collaborators from the BETAUPREG Group (financed by NO Grants 2014– 2021, under Project contract no. 21/2020 (RO-NO-2019-0544), Andreas and Andrei mapped the molecular fingerprint of early insulitis in a cohort of NOD mice ranging from 4 to…