Category: Journal Club

1/13/2026 Agnes
1/20/2026 Shayla
1/27/2026 Lucas
2/3/2026 Ulrik
2/10/2026 Olena
2/17/2026 Kayko
3/3/2026 Fatemeh

Journal Club: Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation

by Fatemeh Rahmatabadi Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation. Enzenmüller et al. explore why B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells sometimes resist the BCL-2 inhibitor…

Journal Club: Sex-specific differences in glucose metabolism and pancreatic function in streptozotocin-induced diabetic mice: The protective role of estrogen

Can Sex Difference shape glucose regulation? by Shayla Sharmine This week’s journal club focuses on a study from Biochemical and Biophysical Research Communications (2025) exploring the protective role of estrogen in glucose regulation.  To explore the impact of sex difference,…

Journal Club: CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

by Lucas Unger Yang et al. demonstrate that HHEX is a lineage-restricting transcription factor essential for pancreas specification from foregut progenitors. Through CRISPR-Cas9 loss-of-function screening combined with hiPSC differentiation and single-cell multiomics, the study reveals that deletion of HHEX diverts…