Category: Journal Club

9/23/2025 Georg
9/30/2025 Thomas
10/7/2025 Kayko
10/14/2025 Fatemeh
10/21/2025 Agnes
10/28/2025 Shayla
11/4/2025 Lucas
11/11/2025 Ulrik

Journal Club: CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

by Lucas Unger Yang et al. demonstrate that HHEX is a lineage-restricting transcription factor essential for pancreas specification from foregut progenitors. Through CRISPR-Cas9 loss-of-function screening combined with hiPSC differentiation and single-cell multiomics, the study reveals that deletion of HHEX diverts…