The gut microbiota has garnered significant attention in recent years due to its critical role in maintaining physiological health. A balanced gut microbiota is associated with overall well-being, whereas dysbiosis is linked to the development and progression of various diseases. Consequently, numerous studies aim to elucidate the factors influencing gut microbiota composition.
A recent study published in the Journal of Xenobiotics on January 17, 2025, investigated the potential impact of bisphenol A (BPA) exposure on microbial imbalance and its association with obesity. In this study, the researchers collected fecal samples from 28 Spanish children aged 5 to 11, comprising 15 non-obese and 13 obese participants. The samples were divided into two groups: one cultured with BPA and the other without. The authors observed a significant shift in microbial composition following BPA exposure, with species such as Clostridium perfringens and Clostridium paraputrificum, which were either undetected or present in low abundance in non-exposed samples, appearing in high abundance in BPA-exposed samples. Notably, the microbial profiles of untreated obese samples exhibited similarities to those of BPA-exposed samples.
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Luque, G.; Ortiz, P.; Torres-Sánchez, A.; Ruiz-Rodríguez, A.; López-Moreno, A.; Aguilera, M. Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity. J. Xenobiot. 2025, 15, 14. https://doi.org/10.3390/jox15010014