Another collaborative study carried over during Simona’s sabbatical stay in Prof Charna Dibner research group at University of Geneva aiming at profiling the long-term modifications of lipid metabolism associated with massive weight loss following the Roux-en-Y gastric bypass surgery.
Here, we provide for the first time a detailed analysis of the alterations of lipid homeostasis occurring in the subcutaneous adipose tissue (SAT) collected from the same individuals in parallel to the blood samples, prior to GBS and 1 year later (cohort 1). We also cross-compared these data with our previous lipidomic analyses conducted by the same approach in a cohort of morbid obese patients in serum and visceral adipose tissue (VAT) samples (cohort 2). These analyses suggest a strong perturbation of the sphingolipid metabolism in morbid obese patients that is partly counteracted by a GBS intervention.
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Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery
Authors: Sinturel F, Chera S, Brulhart-Meynet MC, Montoya JP, Lefai E,Jornayvaz FR, D’Angelo G, Jung MK, Pataky Z, Riezman H, Dibner C
iScience, Volume 27, Issue 9110820 September 20, 2024
DOI information: 10.1016/j.isci.2024.110820