Shayla Sharmine

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SCIENTIFIC CAREER

Since 2021

PhD candidate at Center for Diabetes Research, Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway

2018 – 2021 Master in Molecular Biology, Faculty of Mathematics and Natural Science, University of Bergen.

2016 – 2018 Master’s in Criminology and Criminal justice, University of Dhaka, Bangladesh.

2011 – 2016 Bachelor of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh.

PUBLICATIONS while in the lab

  1. Sharmine S, Legøy TA, Unger L, Paulo JA, Ghila L#, Chera S#. Caloric Restriction Substantially Improves Glucose Regulation in Mice With Hnf1a-Deficient Beta-Cells. Acta Physiol (Oxf). 2025 Dec;241(12):e70121. doi: 10.1111/apha.70121.
  2. Unger L, Larsen U, Sharmine S, Hossain MK, Legøy TA, Vaudel M, Ghila L, Chera S. Efficient cytoplasmic cell quantification using a semi-automated FIJI-based tool. Sci Rep. 2025 Jul 28;15(1):27509. doi: 10.1038/s41598-025-12144-x.
  3. Sharmine S, Ghila L.Targeting Inflammation in Type 2 Diabetes: The Emerging Role of Decorin. Acta Physiol (Oxf). 2025 Jun;241(6):e70049 doi: 10.1111/apha.70049

ORAL presentations

  • Shayla Sharmine, Thomas Aga Legøy, Andreas Mathisen, Luiza Ghila, Simona Chera. “Mapping the impact of high fat diet challenge in a HNF1A-MODY mouse model” ” EASD Annual Meeting 2023, 2-6 October 2023 Hamburg, Germany

POSTER presentations

  • Shayla Sharmine,  Luiza Ghila, Simona Chera. Short-term effect of Somatostatin Modulators on Glycemic Control in MODY mice. The Nordic Developmental Biology Societies & Michael Sars Symposium Joint Meeting, 28-31 May 2024, Bergen, Norway
  • Shayla Sharmine, Luiza Ghila, Simona Chera. High Fat Diet challenge in HNF1A MODY mouse model. NorDoc Summer School 16-18 August 2023, Uppsala & Stockholm
  • Shayla Sharmine, Thomas Aga Legøy, Andreas Mathisen, Luiza Ghila, Simona Chera. “Mapping islet architecture changes upon high fat diet challenge in a HNF1A-MODY mouse model”. Diabetesforum 2023, 25-27 April 2023, Oslo, Norway

Journal Club Posts

  1. Chronic intermittent fasting impairs b cell maturation and function in adolescent mice
  2. Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice
  3. Real time somatostatin detection assay reveals somatostatin hypersecretion in T2D patient derived single islets
  4. Sex-specific differences in glucose metabolism and pancreatic function in streptozotocin-induced diabetic mice: The protective role of estrogen

  5. Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

  6. Hepatic Lipid metabolism and Immune pathways are regulated in LncRNA Hnf1aos1-knockdown mice

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