A detailed study into alpha-cells transcriptional changes upon massive ablation of beta-cells carried out in collaboration with Dr. Santiago and Prof. Pedro Herrera groups was published today, and we show that:
- α-cells undergo stage-specific transcriptional changes 5- and 15-days post-diphtheria toxin (DT)-mediated β-cell ablation.
- At 5 days, α-cells transiently upregulate various genes associated with interferon signaling and proliferation, including Interferon Induced Protein with Tetratricopeptide Repeats 3 (Ifit3).
- At 15 days post β-cell ablation, α-cells undergo a transient downregulation of genes from several pathways including Insulin receptor, mTOR and MET signaling.
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Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss
Authors:
BMC Genomics 22, Article number: 585 (2021)
DOI information: https://doi.org/10.1186/s12864-021-07812-x
* Daniel Oropeza, Valentina Cigliola and Agustín Romero contributed equally to this work.
Santiago A. Rodríguez-Seguí and Pedro L. Herrera are Co-senior authors.