I am invited by the organizers to give a talk on Islet Cell-Fate Dynamic at UNIGE’s Diabetes Center Seminar Series. The seminar will take place on October 5th, 2020 at CMU, room B04.2222
Tag: Simona Chera
Interview in our Department’s newsletter
Bergen Stem Cell Consortium Research Seminar
Collaboration Paper: glucose-sensing insulin-secreting human α-cells
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing…
Research Paper: Specific protein signatures related to progression to muscular invasiveness in bladder cancer
Collaboration Paper: Signals modulating identity changes of pancreatic α-cells
The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1-2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plasticity.…