Simona and Luiza will present some work progress on different projects running in the lab at the Bergen Stem Cell Consortium Research Seminar on Friday, 12th of April 2019 at Glasblokkene
Bergen Stem Cell Consortium Research Seminar
Tag: research
Invited Speaker: BRIGITTE GALLIOT
We have the pleasure of hosting Prof. Brigitte Galliot from the Faculty of Sciences, University of Geneva, Switzerland. The seminar is organized in collaboration with SARS and will take place at HiB, Bioblokken 5th floor, Room 520B (Thormøhlensgt. 55, 5006…
Invited Speaker: NATALIA SOSHNIKOVA
We have the pleasure of hosting Dr. Natalia Soshnikova from the Institute of Molecular Biology (IMB), Mainz, Germany. She will talk about the molecular mechanisms of intestinal stem cell specification during development on 18th of January 2018 at BUS1 Pankreas…
FRIPRO Young Talent Research Project
The Norwegian Research Council announced on 7th of December the new list of awardees. We got new funding from FRIPRO for another independent Young Research Talent project: “Characterizing and modulating the insulin-producing beta-cell fate in monogenic diabetes by using novel…
STAMCELLER Young Talent Research Project
The second project of the lab is funded by the Research Council of Norway, as a Young Talent Research Project. This 4-year project is aiming at characterizing the cellular and molecular basis of the gradual failure of insulin-producing β-cells in…
The Novo Nordisk Foundation Excellence Project grant
Diabetes mellitus is a group of metabolic diseases defined by high blood sugar values caused by the inability of the body to produce and/or use insulin. All forms of diabetes are ultimately characterized by a decrease in the number of functional insulin-producing cells (β-cells), hence a cure for insulin-dependent diabetes types will require their regeneration or replacement. Generally, the most efficient regenerative strategies are the ones involving cell self-renewal capacity. Nevertheless, in mammals, the β-cell proliferative capacity is very low after birth and decreases even further with age. The overall aim of this proposal is to elucidate and reverse the molecular age-switch controlling the gradual impairment of β-cell self-renewal potential by using two murine models of monogenic diabetes.
MODY – our research model
MODY (maturity-onset diabetes of the young) is caused by pancreatic beta cell dysfunction due to a single gene mutation affecting both the prenatal and postnatal pancreas development. Importantly, more than 90 % of MODY mutation carriers will develop diabetes during…