Another fruitful collaboration working on proteomics analyses with a team led by Magnus Berle. In this study, we compared two groups of patients with colon cancer with similar stage, stratified based on the presence or absence of recurrence. The main…
We had the pleasure to co-edit a Research Topic at Frontiers in Genetics and Frontiers in Endocrinology, aiming to provide a sample of current work focused on molecular pathways and cellular processes involved in the development, function, and dysfunction of…
I had recently the great pleasure to contribute to a study led by Dr. Seung Kim (Professor in the Department of Developmental Biology, at Stanford University School of Medicine) aiming for the development of B6 RIP-DTR mice, an immunocompetent line…
For the past five years, our collaborator Helge Ræder and us showed that human induced pluripotent stem cells (hiPSC) provide an excellent tool for disease modelling. However, in vitro differentiation is highly sensitive to culture conditions. By re-creating a spatial…
A detailed study into alpha-cells transcriptional changes upon massive ablation of beta-cells carried out in collaboration with Dr. Santiago Rodríguez-Seguí and Prof. Pedro Herrera groups was published today, and we show that: α-cells undergo stage-specific transcriptional changes 5- and 15-days…
Our latest work on iPSC-derived human pancreatic progenitors differentiation is now out for Early View: The main goal of this study was to assess the effects of elevated glucose concentrations exposure during the last stages of guided in vitro differentiation…
Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.…