This study proposes hiPSCs derived SC-islet differentiation as model to study development impact of EDCs on human pancreatic endocrine cell development and maturation. Using a cocktail of BPA, BPS and trans-nonachlor provided comparable results with in vivo studies of fetus exposure to BPA. Congratulations June, Thomas and Lucas!
Our collaboration with our neighbouring lab continues with Ksenia performing quantitative label-free mass spectrometry, by employing both data-dependent and data-independent acquisition methods, on our cell line model for HNF1A “hot-spot” mutation. Lucas performed in vitro differentiation until pancreatic progenitor stage…
Our work on the impact of diet challenges on Hnf1a-deficient beta-cells is now published in Acta Physiologica! Congratulations Shayla, Thomas and Lucas!
A tour-de-force demonstrating the abilities of Lucas‘s quantitation tool (previously available as a preprint) on pancreatic islet cell quantitation is now published in Scientific Reports! The source code of SAM (semi-automated measurement tool) along with all documentation has been deposited…
After many months of persuasion, Lucas published his semi-automated quantification tool that he developed over 3 years of quantification of thousands of sc-islets and pancreatic sections. His tool is now available both in GitHUB and as a manuscript (currently as…
Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…
Many congratulations to Jakub and Marc on developing a new Python-based tool called ProHap that constructs protein sequence databases from phased genotypes of reference panels, and comes with pregenerated databases from field-reference haplotype panels. Thus ProHap empowers researchers to account…