Here, we investigated the regenerative response of pancreatic islets following moderate beta-cell loss in mice using two diffenet models: one rapid beta-cell targeted synchronous cell death by using the RIPDTR model, and one slow heterogeneous cell death by using streptozotocin…
Together with our collaborators from the BETAUPREG Group (financed by NO Grants 2014– 2021, under Project contract no. 21/2020 (RO-NO-2019-0544), Andreas and Andrei mapped the molecular fingerprint of early insulitis in a cohort of NOD mice ranging from 4 to…
Here, Andreas built and analysed several timelines along the first year of life of different mouse models to understand how pancreatic endocrine islets are maturing and then age. By combining transgenic systems, global transcriptomics, pathway analysis, cell biology and physiology,…