by Lucas Unger This study explores the development of a potential universal antivenom by combining monoclonal antibodies with a small-molecule inhibitor. By isolating antibodies from a hyperimmune human donor with extensive venom exposure (Tim Friede, who injected himself over 800…
After many months of persuasion, Lucas published his semi-automated quantification tool that he developed over 3 years of quantification of thousands of sc-islets and pancreatic sections. His tool is now available both in GitHUB and as a manuscript (currently as…
by Lucas Unger The differentiation of human pluripotent stem cells into insulin-producing beta cells holds great potential for both transplantation-based treatment of insulin-dependent diabetes and diabetes research. In this study, a comprehensive analysis of publicly available single-cell RNA sequencing data…
During pancreas development the HH-signaling modulations plays an essential role, its inactivation being absolutely required for pancreas organogenesis, even slight ectopic activation compromising this process. Moreover, the pathway also plays a role in adult pancreas regeneration, its inactivation promoting regenerative…
Induced pluripotent stem cells as a source for generating pancreatic islet endocrine cells represent a great research tool for deciphering the molecular mechanisms of lineage commitment, a layered multi-step process. Additionally, targeted gene silencing by using GapmeRs, short antisense oligonucleotides,…
ORCID: Researcher ID: Scopus: Google Scholar: Research Gate: SCIENTIFIC CAREER Since 2021 PhD candidate at Center for Diabetes Research, Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway 2019 – 2021 Master in Biology, Specialization in Molecular Biology,…