We are very happy to annouce the publication of a study led by Dr. Hanne Scholz focusing on cell identity dynamics and insights into insulin secretagogues when employing stem cell-derived islets for disease modeling. Here, Chencheng focused on understanding the…
We are very happy to annouce the publication of a study led by Dr. Hanne Scholz focusing on the impact of glucose concentration in regulating the differentiation of induced pluripotent stem cells toward insulin-producing cells. We previously showed that chronically…
Induced pluripotent stem cells as a source for generating pancreatic islet endocrine cells represent a great research tool for deciphering the molecular mechanisms of lineage commitment, a layered multi-step process. Additionally, targeted gene silencing by using GapmeRs, short antisense oligonucleotides,…
Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.…