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Tag: HNF1A
Research Paper: Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo
We are very happy to share our latest work on how HNF1A’s involvement in GLI3 processing affects pancreatic and intestinal development, using a combination of in vivo work (multiple conditional mouse models) and human iPSC models is now ONLINE ahead of print in Genes and Development
Grant award: FRIPRO Researcher Project for Experienced Scientists
We are very happy and grateful to learn that the Norwegian Research Council @forskningsradet will continue to support our research for the next 5 years! We are delighted to continue our work on HNF1A by adding a Time-Dimension of Islet…
Research Paper: The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop
Here, Andreas built and analysed several timelines along the first year of life of different mouse models to understand how pancreatic endocrine islets are maturing and then age. By combining transgenic systems, global transcriptomics, pathway analysis, cell biology and physiology,…
Research Paper: The GLI code controls HNF1A levels during foregut differentiation
During pancreas development the HH-signaling modulations plays an essential role, its inactivation being absolutely required for pancreas organogenesis, even slight ectopic activation compromising this process. Moreover, the pathway also plays a role in adult pancreas regeneration, its inactivation promoting regenerative…
Research Paper: In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism
Our recent study on iPSC-derived human pancreatic progenitors initial response to in vivo is now published: The main goal of this study was to demultiplex and characterize the initial response of the hiPSC-derived differentiating pancreatic progenitors to the in vivo…