by Fatemeh Rahmatabadi: This week’s journal club focuses on a study from Blood (2017) on JAK1/2 and BCL2 inhibitors in AML
Journal Club: JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell–induced protection of AML
Tag: Fatemeh Rahmatabadi
Journal Club: ERK Activity in Immature Leukemic Cells Drives Clonal Selection during Induction Therapy for Acute Myeloid Leukemia
by Fatemeh Rahmatabadi: This week’s journal club focuses on a study from Scientific Reports (2020) investigating the ERK activity in immature leukemic cells involed in clonal selection in AML
Journal Club: Pharmacology and toxicology of the novel investigational agent Cantrixil
by Fatemeh Rahmatabadi: This week’s journal club focuses on a study from Cancer Chemother. Pharmacol. (2017) promoting Cantrixil as a promising anti-cancer agent targeting resilient cancer-stem–cell populations.
Journal Club: Trametinib Sensitivity is Defined by a Myeloid Differentiation Profile in Acute Myeloid Leukemia
by Fatemeh Rahmatabadi: This week’s journal club focuses on a study from Drugs in R&D (2024) aiming to assess the activity of trametinib against a panel of tumor cells from patients with AML
Journal Club: Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation
by Fatemeh Rahmatabadi Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation. Enzenmüller et al. explore why B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells sometimes resist the BCL-2 inhibitor…
Journal Club: The p38 pathway inhibitor, SB202190, activates MEK/MAPK to stimulate the growth of leukemia cells
by Fatemeh Rahmatabadi This study by Hirosawa et al. investigates the effect of the p38 MAPK inhibitor SB202190 on acute myeloid leukemia (AML) cells. While p38 signaling is typically associated with stress responses and growth inhibition, treatment of AML cell…
Journal Club: ERK1/2 and p38α/β Signaling in Tumor Cell Quiescence: Opportunities to Control Dormant Residual Disease
by Fatemeh Rahmatabadi This article by Sosa et al. explores the biology of disseminated tumor cells (DTCs), which are central to cancer relapses and metastasis. DTCs can spread early during tumor development—even from non-invasive lesions—and persist in distant organs such…