Congratulations to Kayko who received funding from the L. Meltzers Universitetsstiftelse for the proposal titled ”Deciphering the role of WNT4 in bladder cancer using patient-derived organoids”! Bladder cancer (BC) is the most common cancer of the urinary tract and currently…
Here, Kayko investigated the proteomic landscape changes along a timeline within the 12 days of treatment with a potent carcinogen, BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine), to understand how oncogenic transformation occurs in mouse bladder. By combining transgenic models, TMT-plex proteomics, pathway analysis,…
Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent…