For the past five years, our collaborator Helge Ræder and us showed that human induced pluripotent stem cells (hiPSC) provide an excellent tool for disease modelling. However, in vitro differentiation is highly sensitive to culture conditions. By re-creating a spatial…
Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.…
Our study on iPSC-derived human pancreatic progenitors in vitro differentiation is now published: The main goal of this study was to characterize the impact of cell confinement on the pancreatic islet signature during the guided in vitro differentiation of alginate…