Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of…
For courageously defending your PhD thesis today! PhD Thesis Title: “In vitro modulation of pancreatic islet cell fate characterized by mass spectrometry-based proteomics” st opponent: Professor, Per-Ola Carlsson, Uppsala University, Sweden nd opponent: Dr. rer. nat. Natalia Soshnikova, Institute of Molecular Biology…
Here, Thomas was enjoying good company in Oxford at the 3rd Joint EASD Islet and Beta-Cell Workshop. He also did a good job presenting a poster on our work on alginate encapsulation. Lise Bjørkhaug Gundersen, Thomas Aga Legøy, Marie Holm…
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing…
We have the pleasure of hosting Prof. Brigitte Galliot from the Faculty of Sciences, University of Geneva, Switzerland. The seminar is organized in collaboration with SARS and will take place at HiB, Bioblokken 5th floor, Room 520B (Thormøhlensgt. 55, 5006…
One temporary short-term position is now available! The project aims to develop and employ (i) an innovative in vivo system allowing the differentiation, monitoring, retrieval, characterization and modulation of MODY-iPSC-derived β-cells; (ii) methods for characterizing the cellular processes and molecular…
Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent…