The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1-2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plasticity.…
Author: sim
Invited Speaker: NATALIA SOSHNIKOVA
We have the pleasure of hosting Dr. Natalia Soshnikova from the Institute of Molecular Biology (IMB), Mainz, Germany. She will talk about the molecular mechanisms of intestinal stem cell specification during development on 18th of January 2018 at BUS1 Pankreas…
Research Paper: β-cell proteomic landscape in differentiating MODY1 patient iPSC-derived cells
Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of…