Andreas Frøslev Mathisen

 

SCIENTIFIC CAREER

2024    Researcher – Center for Diabetes Research, Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway

2020 – 2024 PhD candidate at Center for Diabetes Research, Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway

2019 – 2020 Technician – Center for Diabetes Research, Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway

2017 – 2019 Master in Biomedical Sciences, Faculty of Medicine, University of Bergen, Credits: 120, Grade: A

2013 – 2017 Bachelor in Biomedical laboratory science, Institute of Technological sciences, Copenhagen University College, Denmark

PUBLICATIONS while in the lab

  1. Mathisen AF, Larsen U, Kavli N, Unger L, Vacaru AM, Daian LM, Vacaru A-M, Herrera PL, Ghila L, Chera S. Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption. Commun Biol 7, 833 (2024). https://doi.org/10.1038/s42003-024-06527-5
  2. *Mathisen AF, *Vacaru AM, Unger L, Lamba EM, Mardare OA, Daian LM, Ghila L, Vacaru AM#, Chera S#. Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset. Sci Rep. 2024 Jun 25;14(1):14669. doi: 10.1038/s41598-024-65454-x. PMID: 38918575
  3. Mathisen AF, Legøy TA, Larsen U, Unger L, Abadpour S, Paulo JA, Scholz H, Ghila L, Chera S. The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop. Mech Ageing Dev. 2024 May 31:111951. doi: 10.1016/j.mad.2024.111951
  4. Unger L, Mathisen AF, Chera S, Legøy TA, Ghila L. The GLI code controls HNF1A levels during foregut differentiation. Int. J. Dev. Biol. 2024; 52: 220 doi: 10.1387/ijdb.230220lg
  5. Mathisen AF, Abadpour S, Legøy TA, Paulo JA, Ghila L, Scholz H, Chera S. Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations. Acta Physiol (Oxf). 2023 Aug 24:e14037. doi: 10.1111/apha.14037. PMID: 37621186
  6. Ghila L#, Legøy TA, Mathisen AF, Abadpour S, Paulo JA, Scholz H, Ræder H, Chera S#. Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors. International Journal of Molecular Sciences. 2021; 22(7):3698. https://doi.org/10.3390/ijms22073698
  7. Legøy TA, Mathisen AF, Salim Z, Vethe H, Bjørlykke Y, Abadpour S, Paulo JA, Scholz H, Raeder H, Ghila L, Chera S. In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism. Frontiers in Cell and Developmental Biology 2020 Feb 25;8:109. eCollection 2020. doi: 10.3389/fcell.2020.00109
  8. Legøy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S. In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica (Oxf) 2020 Apr;228(4):e13433. Epub 2020 Jan 8. doi: 10.1111/apha.13433. PMID:31872528
  9. Bjørlykke Y, Søviknes AM, Hoareau L, Vethe H, Mathisen AF, Chera S, Vaudel M, Ghila LM, Ræder H. Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability. Stem Cells International 2019 Nov 18;2019:8036035. doi: 10.1155/2019/8036035. PMID:31827534

PRIZES

ORAL PRESENTATIONS

  1. Andreas Mathisen “The landscape of islet maturation and ageing is regulated by a signalling loop between Hnf1a and the immune system” 2024, The Nordic Developmental Biology Societies & Michael Sars Symposium Joint Meeting, Bergen, Norway
  2. Andreas Mathisen “Mouse models in diabetes research” Mohn Research Center for Diabetes Precision Medicine (PRESICE-DIA) Seminar 2023, Bergen, Norway
  3. Andreas Mathisen, Thomas Aga Legøy, Ulrik Larsen, Luiza Ghila, and Simona Chera.”Islet Maturation And Ageing Is Governed By The Hnf1a Transcription Factor” EASD Annual Meeting 2023, 2-6 October 2023 Hamburg, Germany
  4. Andreas Mathisen, Thomas Aga Legøy, Ulrik Larsen, Luiza Ghila, and Simona Chera.”Hnf1a Is An Important Regulator in Ageing And Maturation Of Pancreatic Islets” 57th Annual Meeting of the Scandinavian Society for the Study of Diabetes (SSSD2023) 24-26 May 2023 Aarhus Denmark
  5. Andreas Mathisen, Thomas Aga Legøy, Luiza Ghila, and Simona Chera. “Hnf1a is a key regulator of β-cell identity and function”. The 17th Annual Research Presentations arranged by UiB Research School in Clinical Medicine 25-26 January 2023, Bergen, Norway
  6. Andreas Mathisen, Thomas Aga Legøy, Luiza Ghila, and Simona Chera. “Hnf1a is a key regulator of β-cell identity and function”. Diabesity Nordic Meeting 9-11 March 2022, Solstrand, Norway

POSTER PRESENTATIONS

  1. Andreas F Mathisen, Thomas A. Legøy, Luiza Ghila, Simona Chera. “Know your background, know your data”. 3rd Nordic Meeting on Development, Stem Cells and Regeneration, 5-7th October 2022, Copenhagen, Denmark
  2. Andreas F Mathisen, Thomas A. Legøy, Luiza Ghila, Simona Chera. “Mind your background!”. European Islet Study Group Workshop,13-15th June 2022, Strasbourg, France 
  3. Andreas Mathisen, Thomas Aga Legøy, Luiza Ghila, and Simona Chera. “Hnf1a is a key regulator of β-cell identity and function”. Diabesity Nordic Meeting 9-11 March 2022, Solstrand, Norway

FUNDING

 

Agency logo Period Grant Description
2020-2021

UiB Research Scholarship for a stay abroad

One year research stay at the University of Geneva, Switzerland, hosted by Prof. Pedro Herrera. The aim of the planned research is to identify the cell fate decisions and molecular changes that contribute to the altered islet architecture through the use of advanced transgenic lineage tracing.
2020-2024 PhD Project: In vivo regeneration of insulin-expressing β-cells
We plan to use complex genetic setups to dynamically characterize the surviving β-cell reply to injury and to stress, then subsequently foster their regeneration by reactivating/maintaining specific molecular switches.