Another fruitful collaboration working on proteomics analyses with a team led by Magnus Berle. In this study, we compared two groups of patients with colon cancer with similar stage, stratified based on the presence or absence of recurrence.
The main aim of this study was to identify proteins associated with relapse, which could provide an improved selection of the patients needing adjuvant therapy after surgery. This work was also a feasibility study considering the limited material available in order to assess the value of large-scale proteomic analyses of perioperative biopsies from colon cancer patients.
The results of this study were published today, showing that signalling related to immune activation and inflammation were the top canonical pathways associated with relapse.
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Cancer Genomics & Proteomics 2022