Here, Andreas built and analysed several timelines along the first year of life of different mouse models to understand how pancreatic endocrine islets are maturing and then age. By combining transgenic systems, global transcriptomics, pathway analysis, cell biology and physiology,…
During pancreas development the HH-signaling modulations plays an essential role, its inactivation being absolutely required for pancreas organogenesis, even slight ectopic activation compromising this process. Moreover, the pathway also plays a role in adult pancreas regeneration, its inactivation promoting regenerative…
Our recent study on iPSC-derived human pancreatic progenitors initial response to in vivo is now published: The main goal of this study was to demultiplex and characterize the initial response of the hiPSC-derived differentiating pancreatic progenitors to the in vivo…