We have the pleasure of hosting Prof. Brigitte Galliot from the Faculty of Sciences, University of Geneva, Switzerland. The seminar is organized in collaboration with SARS and will take place at HiB, Bioblokken 5th floor, Room 520B (Thormøhlensgt. 55, 5006…
Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent…
The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1-2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plasticity.…
Chakravarthy et al. dissect the mechanisms maintaining α cell identity and reveal that simultaneous inactivation of the DNA methyltransferase Dnmt1 and the transcription factor Arx in adult mice drives the conversion of α- to β-like cells. In human T1D islets, glucagon+ cells lose DNMT1 and ARX expression and express β cell markers.
Yesterday it was announced the new members affiliated with NCMM and the Nordic EMBL Partnership in Molecular Medicine, following an open call announced in the spring and with deadline in September, and to our greatest pride, Simona is one of…