Lucas Unger

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SCIENTIFIC CAREER

Since 2021

PhD candidate at Center for Diabetes Research, Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway

2019 – 2021 Master in Biology, Specialization in Molecular Biology, Technical University Darmstadt, Germany

2016 – 2019 Bachelor of Science, University Heidelberg, Germany

PUBLICATIONS while in the lab

  1. Vašíček J, Kuznetsova KG, Skiadopoulou D, Unger L, Chera S, Ghila LM, Bandeira N, Njølstad PR, Johansson S, Bruckner S, Käll L, Vaudel M. ProHap enables human proteomic database generation accounting for population diversity. Nat Methods 9 December 2024 https://doi.org/10.1038/s41592-024-02506-0
  2. Mathisen AF, Larsen U, Kavli N, Unger L, Vacaru AM, Daian LM, Vacaru A-M, Herrera PL, Ghila L, Chera S. Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption. Commun Biol 7, 833 (2024). https://doi.org/10.1038/s42003-024-06527-5
  3. *Mathisen AF, *Vacaru AM, Unger L, Lamba EM, Mardare OA, Daian LM, Ghila L, Vacaru AM#, Chera S#. Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset. Sci Rep. 2024 Jun 25;14(1):14669. doi: 10.1038/s41598-024-65454-x. PMID: 38918575
  4. Mathisen AF, Legøy TA, Larsen U, Unger L, Abadpour S, Paulo JA, Scholz H, Ghila L, Chera S. The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop. Mech Ageing Dev. 2024 May 31:111951. doi: 10.1016/j.mad.2024.111951
  5. Unger L, Mathisen AF, Chera S, Legøy TA, Ghila L. The GLI code controls HNF1A levels during foregut differentiation. Int. J. Dev. Biol. 2024; 52: 220 doi: 10.1387/ijdb.230220lg
  6. Unger L, Ghila L, Chera S.Targeted Gene Silencing by Using GapmeRs in Differentiating Human-Induced Pluripotent Stem Cells (hiPSC) Toward Pancreatic Progenitors. Methods Mol Biol. 2023 Aug 25. doi: 10.1007/7651_2023_498. PMID: 37615889

ORAL PRESENTATIONS

  1. Lucas Unger, Thomas Aga Legøy, Andreas Mathisen, Luiza Ghila, and Simona Chera.”Unraveling the contribution of HNF1A, HNF1B, and HNF4A to monogenic diabetes-associated pancreatic SC-derived islet cell differentiation” EASD Annual Meeting 2023, 2-6 October 2023 Hamburg, Germany
  2. Lucas Unger, Amanda Friestad, Thomas Aga Legøy, Andreas Frøslev Mathisen, Luiza Ghila, Simona Chera.”Exploring the role of transcription factors HNF1A, HNF1B, and HNF4A in human SC-derived pancreatic islet cell differentiation” 57th Annual Meeting of the Scandinavian Society for the Study of Diabetes (SSSD2023) 24-26 May 2023 Aarhus Denmark

POSTER presentations

  1. Lucas Unger, Thomas Aga Legøy, Luiza Ghila, Simona Chera. Exploring hedgehog signaling and HNF1A Crosstalk in HNF1A-MODY stem cell islets EASD Annual Meeting 2024, 9-14 September 2024 Madrid, Spain
  2. Lucas Unger, Andreas F. Mathisen, Thomas Aga Legøy, Simona Chera, Luiza Ghila. Deciphering the HNF1A and Hedgehog Signaling Crosstalk during Stem Cell Islet differentiation, The Nordic Developmental Biology Societies & Michael Sars Symposium Joint Meeting, 28-31 May 2024, Bergen, Norway
  3. Lucas Unger, Luiza Ghila, Simona Chera. “Investigating the developmental role of HNF1A, HNF1B and HNF4A in human pancreatic islet cell differentiation”. 3rd Nordic Meeting on Development, Stem Cells and Regeneration, 5-7th October 2022, Copenhagen, Denmark
  4. Lucas Unger, Thomas Aga Legøy, Luiza Ghila, Simona Chera. “Investigating the developmental role of HNF1A in human pancreatic islet cell differentiation”. Summer School in Transcriptomics 27-30 June 2022 Sandvik Gård, Sweden