During pancreas development the HH-signaling modulations plays an essential role, its inactivation being absolutely required for pancreas organogenesis, even slight ectopic activation compromising this process. Moreover, the pathway also plays a role in adult pancreas regeneration, its inactivation promoting regenerative…
We are very happy to annouce the publication of a study led by Dr. Hanne Scholz focusing on the impact of glucose concentration in regulating the differentiation of induced pluripotent stem cells toward insulin-producing cells. We previously showed that chronically…
We are very happy to annouce the publication of a study led by Prof. Charna Dibner including work that Simona performed during her sabatical year at University of Geneva, during 2020-2021. In a multi-center study, daily regulation of lipid metabolism…
Here, we designed a pilot study to comprehensively identify the diversity of global proteome signatures and the deviation from normal homeostasis in randomly selected human-isolated islet samples. By using Tandem Mass Tag 16-plex proteomics, we focused on the recurrently observed…
Induced pluripotent stem cells as a source for generating pancreatic islet endocrine cells represent a great research tool for deciphering the molecular mechanisms of lineage commitment, a layered multi-step process. Additionally, targeted gene silencing by using GapmeRs, short antisense oligonucleotides,…
We are very happy to annouce the publication of a study led by Dr. Ana Vacaru (Group Leader of the BetaUpreg Research Group, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania) investigating the link between bisphenol A (BPA)…
Congratulations to Andreas Mathisen, our 3rd-year PhD candidate, for receiving FIRST prize for “The Best Oral Presentation Award” at the 17th Annual Research Presentations arranged by the Research School in Clinical Medicine. This event took place between 25 and 26…